Bipolar Disorder: Etiology, Pathogenesis, Diagnosis and Treatments
Submission Deadline: 30 November 2025 (Status: Closed)
Special Issue Editor(s)
Marianna Mazza Email | Website
Department of Psychiatry, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy; Department of Neuroscience, Section of Psychiatry, Università Cattolica del Sacro Cuore, Rome, Italy
Interests: mood disorders; sleep disorders; peripartum; psychotherapy; psychopharmacology; gender psychiatry
Special Issue Information
Dear Colleagues,
Bipolar disorder (BD) is a complex neuropsychiatric condition characterized by recurrent episodes of mood disturbances, including emotional highs (mania or hypomania) and lows (depression). Also referred to as bipolar affective disorder, BD represents one of the leading causes of disability worldwide.
The etiology of BD is multifactorial, involving a complex interplay of genetic predisposition, neurobiological alterations, and environmental factors. Family history plays a significant role. Neurotransmitter imbalances, particularly involving serotonin, dopamine, and norepinephrine, are also implicated in the pathogenesis of BD.
Diagnostic procedures for BD typically encompass a comprehensive clinical evaluation, including a detailed patient history and longitudinal mood charting. This multifaceted approach aids the differential diagnosis of bipolar disorder from other mood disorders. The Diagnosis and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) outlines specific symptomatic criteria and duration for both manic and depressive episodes, which are essential for accurate diagnosis and subsequent treatment planning.
Treatment for bipolar disorder typically encompasses a combination of pharmacological and psychotherapeutic approaches. Pharmacotherapy often includes mood stabilizers, antipsychotics, and antidepressants, which are commonly prescribed to mitigate symptomatology. Concurrent psychotherapeutic interventions and psychosocial programs are implemented to facilitate the development of adaptive coping mechanisms. Early intervention and a tailored treatment plan are crucial for improving outcomes and enhancing the quality of life for affected individuals. Given the frequent comorbidity of psychiatric and chronic medical conditions in this patient population, a multidisciplinary approach that integrates psychiatric and medical healthcare is warranted. This integrated care model aims to achieve optimal therapeutic outcomes through comprehensive management of both psychiatric symptoms and concurrent medical conditions in patients with bipolar disorder.
Dr. Marianna Mazza
Guest Editor
Keywords
bipolar disorder; mania; depression; pharmacotherapy; psychotherapy; personalized care
Manuscript Submission Information
Manuscripts for special issues should be submitted to Actas Españolas de Psiquiatría before the deadline. Research articles, systematic review articles, review articles, case reports, as well as letters are invited. Submissions must align with the journal's aims and scope, and also fit the specific research theme of the special issue. All special issue manuscripts will undergo the same peer review process as regular submissions. The Editor-in-Chief oversees all journal content. If the manuscript is authored by the editor themselves, the editorial team, or family members of the research group, the editor will never be involved in this process; or even if there is a close professional relationship between the author and parties involved in the editorial process. If the editorial team finds a manuscript or an entire special issue does not meet quality standards, it may be rejected. Any disputes arising during the editorial process will be resolved by the Editor-in-Chief. For more information, please refer to the Author Guidelines and Special Issues Guidelines.
Published Paper(s)
Neuroimmune Crossroads: Pathophysiological Links Between Bipolar Disorder and Inflammatory Bowel Disease
1432-1447
Rethinking Treatment-Resistant Depression: A Systematic Review of Novel Therapeutic Strategies and Precision Medicine Approaches
1395-1409
The Promise of Long-acting Injectable Antipsychotics for the Treatment of Bipolar I Disorder: The Role of Manic Predominance
1157-1159
Trace Amine-associated Receptors (TAARs): Candidate Targets in the Treatment of Bipolar Disorders
1140-1153
Critical Overview of Screening Tools for Detecting Bipolar Disorders
Treatment of Bipolar Disorder by a Community Mental Health Service in a Rural Catchment Area in Greece: Treatment Engagement and Outcomes
1011-1019
Antidepressants in Bipolar Depression: From Neurotransmitter Mechanisms to Clinical Challenges
621-631
