Analysis of psychotic disorders in patients with refractory partial epilepsy, psychiatric diagnoses and clinical aspects

Authors

  • L. D’Alessio Center of Epilepsy Referral Neurology Department Hospital Ramos Mejía; First Pharmacology Chair Medical School UBA (University of Buenos Aires); CONICET
  • B. Giagante Center of Epilepsy Referral Neurology Department Hospital Ramos Mejía; First Pharmacology Chair Medical School UBA (University of Buenos Aires); CONICET
  • V. Ibarra Center of Epilepsy Referral Neurology Department Hospital Ramos Mejía; First Pharmacology Chair Medical School UBA (University of Buenos Aires); CONICET
  • C. Papayannis Center of Epilepsy Referral Neurology Department Hospital Ramos Mejía; First Pharmacology Chair Medical School UBA (University of Buenos Aires); CONICET
  • S. Oddo Center of Epilepsy Referral Neurology Department Hospital Ramos Mejía; First Pharmacology Chair Medical School UBA (University of Buenos Aires); CONICET
  • P. Solís Center of Epilepsy Referral Neurology Department Hospital Ramos Mejía; First Pharmacology Chair Medical School UBA (University of Buenos Aires); CONICET
  • D. Consalvo Center of Epilepsy Referral Neurology Department Hospital Ramos Mejía; First Pharmacology Chair Medical School UBA (University of Buenos Aires); CONICET
  • W. Silva Center of Epilepsy Referral Neurology Department Hospital Ramos Mejía; First Pharmacology Chair Medical School UBA (University of Buenos Aires); CONICET
  • V. Donnoli Center of Epilepsy Referral Neurology Department Hospital Ramos Mejía; First Pharmacology Chair Medical School UBA (University of Buenos Aires); CONICET
  • L. M. Zieher Center of Epilepsy Referral Neurology Department Hospital Ramos Mejía; First Pharmacology Chair Medical School UBA (University of Buenos Aires); CONICET
  • S. Kochen Center of Epilepsy Referral Neurology Department Hospital Ramos Mejía; First Pharmacology Chair Medical School UBA (University of Buenos Aires); CONICET

Keywords:

Refractory partial epilepsy, Postictal psychoses, Interictal psychoses, Bimodal psychoses, Bilateral hippocampal sclerosis

Abstract

Introduction. The association between psychotic disorders and epilepsy has been controversial. Different subtypes of psychotic disorders in epilepsy patients have been described according to temporal relationship with seizures-postictal (PIP), interictal (IIP) and bimodal (BP) psychoses are described in literature.

Objectives. Determine clinical characteristics of patients with refractory partial epilepsy and psychoses and compare the results with a control group of patients with refractory partial epilepsy without psychoses.

Methods. A total of 57 patients with refractory partial epilepsy and psychotic disorders (psychotic group [PG]) and 56 patients with refractory partial epilepsy and without psychoses (control group, CG) were evaluated according to DSM-IV criteria and SCID-I. All patients underwent complete neurological, neuroimaging, neuropsychological, and psychiatric assessment. Clinical, demographic and neuroimaging data were compared between patients in CG and PG.

Results. In PG 15 patients (26%) had criteria for PIP, 29 patients (51%) for IIP and 13 patients (23%) for BP. Epilepsy time duration and bilateral hippocampal sclerosis were significantly more frequent in patients with psichosis. PG patients had a longer evolution time of epilepsy and greater frequency of bilateral hippocampal sclerosis (p < 0.05). No differences were found between psychoses subtypes.

Conclusions. Longer evolution of seizures and the presence of bilateral hippocampal sclerosis may increase propensity to develop psychoses in patients with refractory partial epilepsy.

 

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Published

2008-05-01

How to Cite

D’Alessio, L., et al. “Analysis of Psychotic Disorders in Patients With Refractory Partial Epilepsy, Psychiatric Diagnoses and Clinical Aspects”. Actas Españolas De Psiquiatría, vol. 36, no. 3, May 2008, pp. 138-43, https://actaspsiquiatria.es/index.php/actas/article/view/73.

Issue

Vol. 36 No. 3 (2008)

Section

Original