Main points: 1.The study showcased significant reductions in anxiety and depression symptoms among overweight/obese adolescents with depression through an aerobic exercise program. 2. Augmenting conventional care with aerobic exercise management led to substantial improvements in the quality of life for these adolescents. 3. The aerobic exercise program also yielded positive outcomes in terms of weight management, highlighting the efficacy of aerobic exercise in promoting healthy weight management and body composition in this population.