Main points 1.Mental Complications Incidence: Among 80 pancreatic cancer patients, 10.00% were diagnosed with mental complications initially, rising to 15.00% during follow-up. This indicates heightened complication occurrence during treatment. 2.Predictive Factors: Male gender, family income below 3000 yuan, and high baseline sadness scores were identified as predictive factors for mental complications among pancreatic cancer patients. 3.Clinical Suggestions: Clinicians should focus on male patients with lower income and high sadness scores, implementing timely psychological interventions to mitigate complications and improve patient outcomes.