An Epigenetic Manifestation of Alzheimer's Disease: DNA Methylation

Authors

  • Boyi Feng Department of Chronic Disease, Longhua District Center for Chronic Disease Control/Mental Health, 510080 Shenzhen, Guangdong, China; Shenzhen Guangming District People's Hospital, 518107 Shenzhen, Guangdong, China
  • Junli Zheng Department of Chronic Disease, Longhua District Center for Chronic Disease Control/Mental Health, 510080 Shenzhen, Guangdong, China
  • Ying Cai Public Health Service Center, Bao'an District, 518100 Shenzhen, Guangdong, China
  • Yaguang Han First Affiliated Hospital, Heilongjiang University of Chinese Medicine, 150000 Harbin, Heilongjiang, China
  • Yanhua Han First Affiliated Hospital, Heilongjiang University of Chinese Medicine, 150000 Harbin, Heilongjiang, China
  • Jiaqi Wu Department of Chronic Disease, Longhua District Center for Chronic Disease Control/Mental Health, 510080 Shenzhen, Guangdong, China
  • Jun Feng Department of Chronic Disease, Longhua District Center for Chronic Disease Control/Mental Health, 510080 Shenzhen, Guangdong, China
  • Kai Zheng Department of Chronic Disease, Longhua District Center for Chronic Disease Control/Mental Health, 510080 Shenzhen, Guangdong, China

DOI:

https://doi.org/10.62641/aep.v52i3.1595

Keywords:

Alzheimer's disease, DNA methylation, oxidative stress response, inflammatory reaction

Abstract

Alzheimer's disease (AD), the most common form of dementia, has a complex pathogenesis. The number of AD patients has increased in recent years due to population aging, while a trend toward a younger age of onset has arisen, imposing a substantial burden on society and families, and garnering extensive attention. DNA methylation has recently been revealed to play an important role in AD onset and progression. DNA methylation is a critical mechanism regulating gene expression, and alterations in this mechanism dysregulate gene expression and disrupt important pathways, including oxidative stress responses, inflammatory reactions, and protein degradation processes, eventually resulting in disease. Studies have revealed widespread changes in AD patients' DNA methylation in the peripheral blood and brain tissues, affecting multiple signaling pathways and severely impacting neuronal cell and synaptic functions. This review summarizes the role of DNA methylation in the pathogenesis of AD, aiming to provide a theoretical basis for its early prevention and treatment.

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Published

2024-06-05

How to Cite

Feng, Boyi, et al. “An Epigenetic Manifestation of Alzheimer’s Disease: DNA Methylation”. Actas Españolas De Psiquiatría, vol. 52, no. 3, June 2024, pp. 365-74, doi:10.62641/aep.v52i3.1595.

Issue

Section

Review