Bupropion: tolerability and safety

Abstract

Bupropion is an antidepressant thought to work through effects on norepinephrine and dopamine. Favourable aspects of its side-effect profile include low likelihood of somnolence, sexual dysfunction and weight gain. To select a particular antidepressant, side-effects of the drug and their impact on patients’ style of life must be considered. Therefore Bupropion is an ideal option for patients in which sexual dysfunction and weight gain are to be considered. Furthermore, Bupropion has a well established safety profile and when used as directed in the label may in some cases has additional therapeutic benefits.