Serotonin gene polymorphisms in patients with panic disorder

Authors

  • S. Martínez-Barrondo Psychiatry Area Medicine Department University of Oviedo
  • P. A. Saiz Psychiatry Area Medicine Department University of Oviedo
  • B. Morales Molecular Genetics Laboratory University Hospital Central de Asturias
  • M. P. García-Portilla Psychiatry Area Medicine Department University of Oviedo
  • E. Coto Molecular Genetics Laboratory University Hospital Central de Asturias
  • V. Álvarez Molecular Genetics Laboratory University Hospital Central de Asturias
  • J. Bobes Psychiatry Area Medicine Department University of Oviedo

Keywords:

Panic disorder, 5-HT2A polymorphisms, 5-HTT polymorphisms, Association study

Abstract

Introduction. The objetive is to investigate the possible association between four serotonin gene polymorphisms (T102C, A-1438G, 5-HTTLPR and VNTR-5HTT) and panic disorder (PD).

Patients and method. 92 PD outpatients (DSM-IV criteria) and 174 healthy volunteers from Asturias (control group) were included. Polymorphisms were determined after polymerase chain reaction amplification followed by digestion with restriction enzymes and electrophoresis on an agarose gel.

Results. Both 5-HT2A polymorphisms are in complete linkage disequilibrium in our population. No statistically significant differences in genotype frequencies of serotonin gene polymorphisms (T102C, A-1438G, 5HTTLPR, and VNTR-5HTT) were found between patients and control subjects. Allele frequencies did not differ between both groups. No differences were found according to gender.

Conclusions. The polymorphisms studied were not associated with PD in our population. However, larger patient samples are necessary to confirm or reject these findings.

Downloads

Published

2005-07-01

How to Cite

Martínez-Barrondo, S., et al. “Serotonin Gene Polymorphisms in Patients With Panic Disorder”. Actas Españolas De Psiquiatría, vol. 33, no. 4, July 2005, pp. 210-5, https://actaspsiquiatria.es/index.php/actas/article/view/1057.

Issue

Vol. 33 No. 4 (2005)

Section

Original